Environmental and Industrial Biotechnologies

50

employees

35

publications

21.8

million euros portfolio

1,500

sq metres of labs and pilot plant facilities

Global environmental pressures driven by human activity are accelerating the degradation of natural ecosystems and straining the biological resources that underpin food systems, industry, and human well-being. Addressing these interconnected challenges requires integrated approaches that combine sustainable resource use, effective environmental monitoring, cleaner industrial processes, and the ability to translate scientific innovation into real-world solutions. Within this context, the circular bioeconomy offers a unifying framework to reduce environmental impacts while fostering resilience, efficiency, and sustainable development.

Environmental Degradation

Ecosystems worldwide are increasingly degraded by deforestation, soil depletion, overexploitation of resources, and pollution. These pressures weaken ecosystem resilience, reduce biodiversity, and disrupt essential ecological services, heightening vulnerability to climate change.

Pollution and Environmental Monitoring

Water, soil, and air systems are increasingly contaminated by emerging pollutants such as pharmaceuticals, heavy metals, and antimicrobial-resistant microorganisms. Current monitoring approaches often lack the sensitivity and scalability needed for early detection and effective response, underscoring the need for advanced environmental monitoring solutions.

Sustainable Industrial Processes

Conventional industrial processes rely heavily on fossil-based resources and generate significant emissions and waste. Bioprocess-based production, using microbial, plant, or enzymatic systems, provides cleaner, more resource-efficient pathways to produce energy, materials, and chemicals.

Scaling from Lab to Deployment

Transforming laboratory-scale innovations into deployable technologies remains a key challenge. Effective scale-up requires integrated infrastructures that address technical, economic, and regulatory factors, enabling the transition from proof-of-concept research to industrial and societal impact.

Mission

The Environmental & Industrial Biotechnology Unit (BIOTECH) is a multidisciplinary research and development collective dedicated to addressing pressing environmental, industrial, and societal challenges through science-driven innovation. By seamlessly integrating fundamental research, applied innovation, and technological deployment—from industrial research and product development to piloting and prototyping—BIOTECH transforms scientific knowledge into sustainable, bio-based solutions with real-world impact. Central to the Unit’s mission is an impact-driven approach that advances environmental monitoring, risk management, and regulatory translation, ensuring that cutting-edge biotechnology not only generates knowledge but also delivers measurable benefits for ecosystems, industry, and society.

 

One of the Unit’s core objectives is the development of bio-based products using microbial, plant, or enzymatic systems. Research focuses on:

  • High-value biomolecules: Production of pharmaceuticals, enzymes, and specialty chemicals through microbial fermentation or plant molecular farming.
  • Bioenergy and biofuels, chemical building blocks: Generation of renewable energy carriers through microbial consortia or engineered metabolic pathways. Energy and product biorefining.
  • Biopolymers: Synthesis of biodegradable polymers to replace conventional plastics, integrating waste valorisation into product development.

These approaches not only reduce reliance on fossil resources but also exemplify the Unit’s commitment to sustainability and industrial innovation.

BIOTECH actively develops strategies to convert agri-food, industrial, and municipal waste streams into valuable products. This includes:

  • Bioconversion of biomass into bioenergy, biochemicals, or biofertilizers.
  • Integration of circular bioeconomy principles in process design, ensuring that waste products become inputs for further production cycles.

Such strategies align with global priorities to reduce environmental footprints and promote sustainable resource management.

The Unit emphasizes the development of advanced biomonitoring and diagnostic systems, particularly for water quality and pathogen surveillance. Research areas include:

  • Biosensor development: Aptamer-based sensors, analytics, and real-time monitoring platforms. Platforms capable of timely detection and quantification of environmental contaminants and microbial threats.
  • Wastewater epidemiology: Tracking pathogens such as SARS-CoV-2 or antibiotic-resistant bacteria to inform public health interventions.

These tools enhance decision-making for environmental management, public health, and regulatory compliance.

BIOTECH supports the scale-up of bioprocesses from laboratory to pilot and industrial stages. This includes:

  • Process optimization: Maximizing yields, efficiency, and cost-effectiveness.
  • Techno-economic assessment: Evaluating feasibility, sustainability, and market potential.
  • Integration into existing infrastructure: Ensuring compatibility with industrial production systems.

By coupling scientific innovation with economic and operational evaluation, BIOTECH ensures that its solutions are viable and scalable.

Partnership with industry and regulatory bodies is central to the Unit’s mission. In internal cooperation with other LIST actors, we are able to contribute to:

  • Technology transfer: Licensing, spin-off creation, and commercialization of innovations.
  • Regulatory compliance: Ensuring processes and products meet national and international standards.
  • Public-private partnerships: Facilitating co-development projects with industrial partners.
  • Spin-Off creation, entrepreneurs-in-residence, venture capital, public funding.

Through these mechanisms, BIOTECH bridges the gap between research outputs and real-world application.

Scope of expertise

The Unit’s expertise spans multiple disciplines and technical platforms, allowing it to address complex environmental and industrial challenges effectively.

It focuses on scaling bench-scale bioproduction, encompassing recovery, purification, and formulation. Expertise in process integration ensures that lab-scale innovations can be translated into industrially relevant products.

It investigates microbial populations in water, food, and environmental matrices, addressing public health threats, pathogen fate, and microbial risk. Includes sewer-based epidemiology, with applications in tracking viruses such as SARS-CoV-2. Specializes in biosensor development, microbial risk assessment, pathogen tracking, and probiotic-based remediation.

It uses microbial consortia for renewable energy and biorefining. Focuses on engineering microbial communities to enhance bioprocess efficiency and environmental remediation.

It develops plant-cell platforms to produce bioactive compounds for pharmaceuticals and industrial applications. Enables scalable, sustainable production of complex biomolecules.

The unit provides full-chain support from research to pilot-scale deployment. Equipped for bioprocess scaling, biorefinery development, water treatment technologies, and environmental monitoring. Supports companies in translating scientific research into industrial solutions. Engages in collaborative research with companies and regulatory bodies. Facilitates technology transfer, licensing, and spin-off creation. Leverages Luxembourg’s innovation ecosystem to accelerate commercialization.

Facilities include biosafety level 2 labs and Pilot Halls. Supports comprehensive analysis, development, and validation workflows. Comprises a team of over 50 scientists and engineers. Houses 1500+ m² of bioprocess engineering space capable of supporting research from concept to industrial readiness.

In cooperation with other units within LIST, the unit focuses on Biomanufacturing & Biorefining. Indeed, it conducts sustainability evaluation using life cycle assessments (LCAs). Provides regulatory compliance and risk assessment services. Develops “safer and sustainable by design” strategies for chemicals and processes.

BIOTECH integrates scientific research, technological innovation, and industrial application to tackle complex global challenges. Its interdisciplinary approach ensures that environmental monitoring, bioprocessing, and bio-based product development are connected across scales—from lab to pilot, and from pilot to industry.

The Unit’s work contributes to:

  • Sustainable industrial production: Providing bio-based alternatives for chemicals, materials, and energy.
  • Environmental protection and public health: Enhancing monitoring systems for water and wastewater, including advanced pathogen surveillance.
  • Circular bioeconomy: Valorising waste streams and reducing environmental footprints.
  • Policy and regulatory frameworks: Offering data-driven insights for regulatory decision-making and industrial compliance.

By combining expertise in microbiology, plant molecular farming, downstream bioprocessing, biosensor development, risk assessment, and sustainability, BIOTECH is uniquely positioned to translate scientific innovation into real-world solutions.

Our latest projects

microPLAstox

Oral exposure to bio-based versus conventional nanoplastics: unravelling health hazards in humans using hand-in-hand in vitro gut models and multiscale analytics

ExtraBark

Towards a Strengthened Circular Economy for Valuing Wood Bark By-products through the Extraction of Valuable Molecules as Alternatives to Synthetic Products in Agronomy and Wood Protection

SUPERVIR

Establishment of a permanent wastewater surveillance system for key viral pathogens of concern in Luxembourg

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Our latest publications

Novel approaches to functional studies of stress-related proteins in wheat and barley: Genetic engineering, proteoforms, organellar proteomics, interactomics and proxiomics

Kosová K., Sergeant K., Xu X., Nešporová T., Vítámvás P., Klíma M., Prášil I.T., Ovesná J., Renaut J.

Plant Stress, vol. 21, art. no. 101353, 2026

Chlorella vulgaris protein isolate effectively protects Lacticaseibacillus rhamnosus GG viability during processing, storage, and in vitro digestion

Fortuin J., Leclercq C.C., Silva R.K., Shaplov A.S., Contal S., Cambier S., Iken M., Fogliano V., Soukoulis C.

Food Hydrocolloids, vol. 172, art. no. 111999, 2026

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